Assuntos
Hemorragia Cerebral/etiologia , Vasculite por IgA/complicações , Vasculite por IgA/diagnóstico , Síndrome da Leucoencefalopatia Posterior/etiologia , Adolescente , Hemorragia Cerebral/sangue , Hemorragia Cerebral/diagnóstico por imagem , Produtos de Degradação da Fibrina e do Fibrinogênio/metabolismo , Humanos , Vasculite por IgA/tratamento farmacológico , Masculino , Síndrome da Leucoencefalopatia Posterior/sangue , Síndrome da Leucoencefalopatia Posterior/diagnóstico por imagemRESUMO
Henoch-Schönlein Purpura (HSP, IgA vasculitis) is an immunoglobulin A (IgA) mediated disorder characterized by systemic vasculitis with variable presentation, frequently affecting the skin, mucous membrane, joints, kidneys, and rarely lungs and the central nervous system. Interestingly, enhanced production of interleukin-8 (IL-8) levels are found during active disease and increased levels have been reported in supernatants from human umbilical venous endothelial cells after stimulation with sera from patients affected by HSP. While corticosteroid therapy is currently the recommended treatment for HSP, dapsone, an anti-leprosy agent, has also recently been suggested to have therapeutic efficacy due to its ability to suppress IL-8. Moreover, in addition to IL-8 suppression, dapsone has been reported to exert various anti-inflammatory effects by inhibiting the generation of toxic free radicals, myeloperoxidase mediated halogenation that converts H2O2 to HOCl, leukocyte chemotaxis, production of tumor necrosis factor, and other anti-inflammatory molecules. This review aims to provide a solid hypothesis for the pathogenesis of vasculitis in HSP. Moreover, we highlight potential mechanistic actions of dapsone in hopes that dapsone may be considered as an alternative viable treatment for patients affected by HSP.
Assuntos
Dapsona/uso terapêutico , Vasculite por IgA/tratamento farmacológico , Corticosteroides/uso terapêutico , Anti-Inflamatórios/uso terapêutico , Quimiotaxia , Citocinas/metabolismo , Radicais Livres , Células Endoteliais da Veia Umbilical Humana , Humanos , Peróxido de Hidrogênio/química , Imunoglobulina A/imunologia , Interleucina-8/metabolismo , Leucócitos/citologia , Modelos Biológicos , Neutrófilos/metabolismo , Oxigênio/química , Peroxidase/metabolismo , Vasculite/tratamento farmacológicoRESUMO
Dapsone is a sulfone essentially used to treat leprae. We describe, here, a somewhat rare indication of dapsone: corticoid sparing in the treatment of particular forms of Henoch-Schönlein.